During 1793, West Indies, St Domingo. During its stay in St Domingo the 49th took part in many of the various actions. The campaign as a whole could not be considered a success owing to the loss, due to fever and other illnesses. Although many individual actions achieved their objects, the 49th was reduced to a handful of men
On 9 Sept 1793, West Indies, Jamaica, Port Augusta. In early September the Flank companies of the 49th sailed for St Domingo under the command of Lieutenant Colonel Whitlock, arriving at Jeremie on 9 September.
On 11 October five Battalion companies were transported on the 'Iphigenia' and 'Penelope' to Mole St Nicholas.
The three remaining companies left on 13 October
During 1796, West Indies, St. Domingo. Sometime during 1796 the Regiment sailed here, where they were employed against the Maroons. In the operations over this and the following year they were to lose 25 officers and the greater part of the men, the few remaining were drafted and the skeleton of the Regiment ordered to England where they landed at Portsmouth
On 21 Feb 1796, Haiti, Port au Prince. As part of a large force, landed at Port au Prince an, on 28 February, the Regiment was involved in an attack on a Negro camp at Turgest which commanded the water supply, and was successfully concluded.
During 1798, England, Exeter. During the year of 1798 recruiting from the supplementary militia took place. They were formed into a Light Infantry Battalion and detached into Cornwall with some militia light companies. Headquarters of the Battalion moved to South Molton, and from there to Helston in Cornwall